Title : Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response.

Pub. Date : 2021 Jan 6

PMID : 33414432






1 Functional Relationships(s)
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1 Here, we report that lysosomotropic agents, including azithromycin, chloroquine, and hydroxychloroquine, can trigger eIF2alpha phosphorylation in vitro (in cultured human cells) and, as validated for hydroxychloroquine, in vivo (in mice). Azithromycin eukaryotic translation initiation factor 2A Homo sapiens