Title : Targeting ACSS2 with a Transition-State Mimetic Inhibits Triple-Negative Breast Cancer Growth.

Pub. Date : 2021 Mar 1

PMID : 33414169






3 Functional Relationships(s)
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1 Recent studies have shown that cancer cells upregulate acetyl-CoA synthetase 2 (ACSS2), an enzyme that converts acetate to acetyl-CoA, in response to stresses such as low nutrient availability and hypoxia. Acetates acyl-CoA synthetase short chain family member 2 Homo sapiens
2 Recent studies have shown that cancer cells upregulate acetyl-CoA synthetase 2 (ACSS2), an enzyme that converts acetate to acetyl-CoA, in response to stresses such as low nutrient availability and hypoxia. Acetates acyl-CoA synthetase short chain family member 2 Homo sapiens
3 Stressed cancer cells use ACSS2 as a means to exploit acetate as an alternative nutrient source. Acetates acyl-CoA synthetase short chain family member 2 Homo sapiens