Title : Identifying the Dominant Contribution of Human Cytochrome P450 2J2 to the Metabolism of Rivaroxaban, an Oral Anticoagulant.

Pub. Date : 2022 Feb

PMID : 33411110






1 Functional Relationships(s)
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1 In addition, rivaroxaban hydroxylation was inhibited by 41.1% in the presence of the CYP2J2-specific inhibitor danazol, which was comparable to the inhibition rate of 43.3% by the CYP3A-specific inhibitor ketoconazole in mixed HLMs. Ketoconazole cytochrome P450 family 3 subfamily A member 4 Homo sapiens