Title : Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission.

Pub. Date : 2021

PMID : 33408784






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Anti-allergic drug azelastine suppresses colon tumorigenesis by directly targeting ARF1 to inhibit IQGAP1-ERK-Drp1-mediated mitochondrial fission. azelastine utrophin Homo sapiens
2 Mechanistically, azelastine bound to Thr-48 in ARF1 and repressed its activity, decreasing Drp1 phosphorylation. azelastine utrophin Homo sapiens