Title : Dual-Mode Cross-Linking Enhances Adhesion of Silk Fibroin Hydrogels to Intestinal Tissue.

Pub. Date : 2019 Jul 8

PMID : 33405568






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Distinct from a previous approach to functionalize silk directly with catechol groups, this work investigated in situ generation of catechol on silk fibroin by enzymatically modifying phenolic side chains, where it was found that this enzymatic approach led to conjugates with higher degrees of catechol functionalization and aqueous solubility. catechol fibroin light chain Bombyx mori
2 Distinct from a previous approach to functionalize silk directly with catechol groups, this work investigated in situ generation of catechol on silk fibroin by enzymatically modifying phenolic side chains, where it was found that this enzymatic approach led to conjugates with higher degrees of catechol functionalization and aqueous solubility. catechol fibroin light chain Bombyx mori
3 Silk fibroin was functionalized with tyramine to enrich the protein"s phenolic side chains, which were subsequently oxidized into catechol groups using mushroom tyrosinase (MT). catechol fibroin light chain Bombyx mori
4 Phenolic functionalization and oxidative cross-linking of silk fibroin was found to afford a new route to water-soluble, catechol-functionalized polymers, which were found to display excellent adhesion to mucosal tissue and whose secondary structure provides an additional mode to control strength and swelling of adhesive gels. catechol fibroin light chain Bombyx mori