Title : Mussel-Inspired Surface Immobilization of Heparin on Magnetic Nanoparticles for Enhanced Wound Repair via Sustained Release of a Growth Factor and M2 Macrophage Polarization.

Pub. Date : 2021 Jan 20

PMID : 33403850






7 Functional Relationships(s)
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1 Herein, based on the Fe3O4 nanoparticle, we developed a fibroblast growth factor (bFGF)-loaded Fe3O4 nanoparticle using a simple mussel-inspired surface immobilization method. ferryl iron fibroblast growth factor 2 Homo sapiens
2 Herein, based on the Fe3O4 nanoparticle, we developed a fibroblast growth factor (bFGF)-loaded Fe3O4 nanoparticle using a simple mussel-inspired surface immobilization method. ferryl iron fibroblast growth factor 2 Homo sapiens
3 This nanoparticle, named as bFGF-HDC@Fe3O4, could stabilize bFGF in various conditions and exhibited sustained release of bFGF. ferryl iron fibroblast growth factor 2 Homo sapiens
4 This nanoparticle, named as bFGF-HDC@Fe3O4, could stabilize bFGF in various conditions and exhibited sustained release of bFGF. ferryl iron fibroblast growth factor 2 Homo sapiens
5 This nanoparticle, named as bFGF-HDC@Fe3O4, could stabilize bFGF in various conditions and exhibited sustained release of bFGF. ferryl iron fibroblast growth factor 2 Homo sapiens
6 In addition, an in vitro study discovered that bFGF-HDC@Fe3O4 could promote macrophage polarization toward an anti-inflammatory (pro-healing) M2 phenotype especially under eMF. ferryl iron fibroblast growth factor 2 Homo sapiens
7 Further, in vivo full-thickness wound animal models demonstrated that bFGF-HDC@Fe3O4 could significantly accelerate wound healing through M2 macrophage polarization and increased cell proliferation. ferryl iron fibroblast growth factor 2 Homo sapiens