Title : Effects of CYP2D6, CYP3A5, and ABCB1 gene polymorphisms on the pharmacokinetics of two risperidone long-acting injection microsphere formulations.

Pub. Date : 2021 Jul 13

PMID : 33400943






1 Functional Relationships(s)
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1 RESULTS: The risperidone Cmax,ss, Cmin,ss, AUC0-tau,ss, and the ratio of risperidone to 9-hydroxyrisperidone (9-OH-R) in CYP2D6 intermediate metabolizers (IMs) were significantly different compared with those in normal metabolizers (NMs) in both the LY03004 and Risperdal Consta groups (P < 0.05). Paliperidone Palmitate cytochrome P450 family 2 subfamily D member 6 Homo sapiens