Title : Species-specific differences in the inhibition of 11β-hydroxysteroid dehydrogenase 2 by itraconazole and posaconazole.

Pub. Date : 2021 Feb 1

PMID : 33387577






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Recently, the azole antifungals itraconazole and posaconazole were identified to potently inhibit human 11beta-HSD2, and several case studies described patients with acquired AME. Azoles hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens
2 The results provide an explanation for the observed species-specific 11beta-HSD2 inhibition by the studied azole antifungals. Azoles hydroxysteroid 11-beta dehydrogenase 2 Homo sapiens