Pub. Date : 2021 Mar
PMID : 33384383
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional characterization of 40 CYP3A4 variants by assessing midazolam 1"-hydroxylation and testosterone 6beta-hydroxylation. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In this study, we characterized wild-type CYP3A4 and 40 CYP3A4 variants, including 11 new variants, detected among 4,776 Japanese individuals by assessing CYP3A4 enzymatic activities for two representative substrates (midazolam and testosterone). | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | In this study, we characterized wild-type CYP3A4 and 40 CYP3A4 variants, including 11 new variants, detected among 4,776 Japanese individuals by assessing CYP3A4 enzymatic activities for two representative substrates (midazolam and testosterone). | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | The kinetic parameters of midazolam and testosterone hydroxylation by wild-type CYP3A4 and 29 CYP3A4 variants (Km , kcat , and catalytic efficiency) were determined, and the causes of their kinetic differences were evaluated by three-dimensional structural modeling. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | The kinetic parameters of midazolam and testosterone hydroxylation by wild-type CYP3A4 and 29 CYP3A4 variants (Km , kcat , and catalytic efficiency) were determined, and the causes of their kinetic differences were evaluated by three-dimensional structural modeling. | Testosterone | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |