Pub. Date : 2021 Feb 15
PMID : 33373654
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Rho kinase inhibitor (Fasudil) suppresses TGF-beta mediated autophagy in urethra fibroblasts to attenuate traumatic urethral stricture (TUS) through re-activating Akt/mTOR pathway: An in vitro study. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | In addition, TGF-beta treatment decreased the expression levels of phosphorylated Akt (p-Akt) and mTOR (p-mTOR) to inactivate the Akt/mTOR pathway in the PUFs, which could be re-activated by Fasudil. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Then, the fibroblasts were treated with the Pan-Akt inhibitor (GDC-0068), and we surprisingly found that GDC-0068 abrogated the inhibiting effects of Fasudil on cell autophagy and proliferation in the PUFs treated with TGF-beta. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | SIGNIFICANCE: Fasudil regulated Akt/mTOR pathway mediated autophagy to hamper TGF-beta-mediated super-activation in PUFs, which supported that Fasudil might be an ideal candidate therapeutic agent for TUS treatment for clinical utilization. | fasudil | AKT serine/threonine kinase 1 | Homo sapiens |