Pub. Date : 2020 Nov
PMID : 33372901
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of female sex hormones estradiol and progesterone on P-glycoprotein (Pgp) functioning have been investigated using Caco-2 cells. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The effects of female sex hormones estradiol and progesterone on P-glycoprotein (Pgp) functioning have been investigated using Caco-2 cells. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Incubation of these cells with 100 muM progesterone for 3 days increased Pgp synthesis, but its activity remained unchanged due to non-genomic (direct) inhibition of Pgp molecule by gestagen. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Incubation of these cells with 100 muM progesterone for 3 days increased Pgp synthesis, but its activity remained unchanged due to non-genomic (direct) inhibition of Pgp molecule by gestagen. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | The pregnan-X receptor inhibitor (PXR), ketoconazole suppressed the inducing effect of progesterone on Pgp synthesis. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The combination of 10 muM estradiol and 100 muM progesterone increased Pgp synthesis, but did not increase the transporter protein activity, due to direct inhibition of the Pgp molecule by progestogen. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The combination of 10 muM estradiol and 100 muM progesterone increased Pgp synthesis, but did not increase the transporter protein activity, due to direct inhibition of the Pgp molecule by progestogen. | Progesterone | ATP binding cassette subfamily B member 1 | Homo sapiens |