Pub. Date : 2021 Jan
PMID : 33360346
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transcriptomics and bioinformatics results indicated that URE could regulate glutamatergic, cholinergic, serotonergic, and GABAergic systems, especially neuroactive ligand-receptor and cAMP signaling pathways, revealing that Htr1a encoding 5-HT1A receptor was a potential target of URE. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | Transcriptomics and bioinformatics results indicated that URE could regulate glutamatergic, cholinergic, serotonergic, and GABAergic systems, especially neuroactive ligand-receptor and cAMP signaling pathways, revealing that Htr1a encoding 5-HT1A receptor was a potential target of URE. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | Transcriptomics and bioinformatics results indicated that URE could regulate glutamatergic, cholinergic, serotonergic, and GABAergic systems, especially neuroactive ligand-receptor and cAMP signaling pathways, revealing that Htr1a encoding 5-HT1A receptor was a potential target of URE. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 4 | Transcriptomics and bioinformatics results indicated that URE could regulate glutamatergic, cholinergic, serotonergic, and GABAergic systems, especially neuroactive ligand-receptor and cAMP signaling pathways, revealing that Htr1a encoding 5-HT1A receptor was a potential target of URE. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 5 | The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 6 | The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 7 | The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 8 | The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 9 | The expression levels of downstream proteins of 5-HT1A signaling pathway 5-HT1A, CREB, BDNF, and PKA were increased in UCMS-induced mice after URE administration, and URE also displayed an agonistic effect against 5-HT1A receptor with an EC50 value of 17.42 mug/ml. | Urea | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |