Pub. Date : 2021 Jan 12
PMID : 33350827
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cholesterol Asymmetrically Modulates the Conformational Ensemble of the Nucleotide-Binding Domains of P-Glycoprotein in Lipid Nanodiscs. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We aimed to determine the effects of cholesterol in a membrane on the conformational behavior of P-gp in lipid nanodiscs. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Hydrogen/deuterium exchange mass spectrometry demonstrates that cholesterol in the membrane induces asymmetric, long-range changes in the distributions and exchange kinetics of conformations of the nucleotide-binding domains, correlating the effects of lipid composition on activity with specific changes in the P-gp conformational landscape. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |