Pub. Date : 2021 Apr 30
PMID : 33350292
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism. | Metformin | tumor protein p53 | Homo sapiens |
| 2 | AIM: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1 and Tp53, and apoptosis in primary breast cancer cells (PBCCs). | Metformin | tumor protein p53 | Homo sapiens |
| 3 | 25mM dose of metformin increased p53 expression significantly compared with the non-treated group. | Metformin | tumor protein p53 | Homo sapiens |
| 4 | CONCLUSION: Metformin can modulate cyclin D1 and p53 expression through AMPK-alpha independent mechanism in breast cancer cells, leading to cell proliferation inhibition and apoptosis induction. | Metformin | tumor protein p53 | Homo sapiens |