Pub. Date : 2021
PMID : 33349212
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 3-MA Enhanced Chemosensitivity in Cisplatin Resistant Hypopharyngeal Squamous Carcinoma Cells via Inhibiting Beclin -1 Mediated Autophagy. | 3-methyladenine | beclin 1 | Homo sapiens |
| 2 | Furthermore, Western blot showed that expression of Beclin1, lc3-I, lc3-II, atg-5 protein decreased significantly after 3-MA intervention, while the expression of p62 up-regulated, which also confirmed autophagy flow was blocked. | 3-methyladenine | beclin 1 | Homo sapiens |
| 3 | The use of 3-MA can significantly reduce autophagy level and arresting its cell cycle, promote apoptosis and reverse the cisplatin resistance condition, this effect is partly mediated by inhibition of Beclin-1 expression. | 3-methyladenine | beclin 1 | Homo sapiens |