Title : IL-6 promotes nuclear translocation of HIF-1α to aggravate chemoresistance of ovarian cancer cells.

Pub. Date : 2021 Mar 5

PMID : 33345849






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Proliferation assay and apoptosis assay were applied and proved that IL-6 enhances the chemoresistance of OvCa cells against cisplatin through the upregulation of HIF-1alpha via the STAT3 signaling in vitro. Cisplatin interleukin 6 Homo sapiens
2 The In vivo studies confirmed the effect of IL-6 in increasing the chemoresistance of OvCa cells against cisplatin through the IL-6/STAT3/HIF-1alpha loop in the animal models. Cisplatin interleukin 6 Homo sapiens