Title : Induction of HO-1 by 5, 8-Dihydroxy-4',7-Dimethoxyflavone via Activation of ROS/p38 MAPK/Nrf2 Attenuates Thrombin-Induced Connective Tissue Growth Factor Expression in Human Cardiac Fibroblasts.

Pub. Date : 2020

PMID : 33343802






3 Functional Relationships(s)
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1 Interestingly, pretreatment with glutathione (GSH) inhibited DDF-induced HO-1 expression. Glutathione heme oxygenase 1 Homo sapiens
2 Interestingly, pretreatment with glutathione (GSH) inhibited DDF-induced HO-1 expression. Glutathione heme oxygenase 1 Homo sapiens
3 Interaction between Nrf2 and the ARE-binding sites on the HO-1 promoter was revealed by chromatin immunoprecipitation assay, which was attenuated by NAC, GSH, or p38i VIII. Glutathione heme oxygenase 1 Homo sapiens