Title : After cyclophosphamide exposure, granulosa cells recover their anti-müllerian hormone-producing ability but not their numbers.

Pub. Date : 2021 Aug

PMID : 33342073






7 Functional Relationships(s)
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1 However, women who have undergone cyclophosphamide (Cy) treatment have decreased AMH levels due to damaged GCs. Cyclophosphamide anti-Mullerian hormone Homo sapiens
2 However, women who have undergone cyclophosphamide (Cy) treatment have decreased AMH levels due to damaged GCs. Cyclophosphamide anti-Mullerian hormone Homo sapiens
3 This study establishes flow cytometry protocols for identification of GCs and investigates the cause of the Cy-induced AMH decrease by analyzing the number of GCs and their AMH production at the single cell level. Cyclophosphamide anti-Mullerian hormone Homo sapiens
4 This study establishes flow cytometry protocols for identification of GCs and investigates the cause of the Cy-induced AMH decrease by analyzing the number of GCs and their AMH production at the single cell level. Cyclophosphamide anti-Mullerian hormone Homo sapiens
5 Consistently, in vitro, Cy-induced low AMH production in FSHR+ AMH+ hGL5 cells (immortalized human GCs) was restored 24 h after Cy treatment, although their numbers remained decreased. Cyclophosphamide anti-Mullerian hormone Homo sapiens
6 Consistently, in vitro, Cy-induced low AMH production in FSHR+ AMH+ hGL5 cells (immortalized human GCs) was restored 24 h after Cy treatment, although their numbers remained decreased. Cyclophosphamide anti-Mullerian hormone Homo sapiens
7 Thus, the surviving GCs after Cy exposure had intact AMH-producing ability. Cyclophosphamide anti-Mullerian hormone Homo sapiens