Title : Distinct GluN1 and GluN2 Structural Determinants for Subunit-Selective Positive Allosteric Modulation of N-Methyl-d-aspartate Receptors.

Pub. Date : 2021 Jan 6

PMID : 33326224






1 Functional Relationships(s)
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1 Here we describe modest changes to the tetrahydroisoquinoline scaffold of GluN2C/GluN2D-selective PAMs that expands activity to include GluN2A- and GluN2B-containing recombinant and synaptic NMDARs. 1,2,3,4-tetrahydroisoquinoline glutamate ionotropic receptor NMDA type subunit 2B Homo sapiens