Title : Modulating glutathione thiol status alters pancreatic β-cell morphogenesis in the developing zebrafish (Danio rerio) embryo.

Pub. Date : 2021 Jan

PMID : 33321464






7 Functional Relationships(s)
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1 Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
2 Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
3 Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
4 Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
5 Nrf2a was also stabilized in beta-cells: 10-min exposures to 77.6 muM tert-butylhydroperoxide significantly increased Nrf2a protein compared to control islet cells that largely lack stabilized Nrf2a; 10-min exposures to higher (776 muM) tert-butylhydroperoxide concentration stabilized Nrf2a throughout the pancreas. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
6 The 10-min high (776 muM) tert-butylhydroperoxide exposure (induced Nrf2a globally) decreased global protein glutathionylation at 96 hpf. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio
7 Mutant fish expressing inactive Nrf2a were protected against tert-butylhydroperoxide-induced abnormal islet morphology. tert-Butylhydroperoxide nfe2 like bZIP transcription factor 2a Danio rerio