Title : Combined Structure and Ligand-Based Design of Selective Acetylcholinesterase Inhibitors.

Pub. Date : 2021 Jan 25

PMID : 33320652






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Three of the 24 compounds (compounds 10b, 10h, and 10i) based on a 6-(2-(pyrrolidin-1-yl)pyrimidin-4-yl)-thiazolo[3,2-a]pyrimidine scaffold showed highly promising AChE inhibition ability with IC50 values of 13.10 +- 0.53, 16.02 +- 0.46, and 6.22 +- 0.54 muM, respectively. 6-(2-(pyrrolidin-1-yl)pyrimidin-4-yl)-thiazolo[3,2-a]pyrimidine acetylcholinesterase (Cartwright blood group) Homo sapiens