Title : NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro.

Pub. Date : 2020 Dec 15

PMID : 33319867






1 Functional Relationships(s)
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1 Treatment with NAD + precursor nicotinamide increases the intracellular NAD + level and re-balances the NAD + /NADH ratio, with enhanced Sirt-1 activity in hMSCs at high passage, partially restores mitochondrial fitness and rejuvenates senescent hMSCs. Niacinamide sirtuin 1 Homo sapiens