Title : VHL gene methylation contributes to excessive erythrocytosis in chronic mountain sickness rat model by upregulating the HIF-2α/EPO pathway.

Pub. Date : 2021 Feb 1

PMID : 33309718






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The DNA methyltransferase inhibitor 5-azacytidine reduced chronic hypoxia-induced erythroid proliferation in the bone marrow of rats with CMS by suppressing VHL methylation and DNMTs expression. Azacitidine von Hippel-Lindau tumor suppressor Rattus norvegicus
2 We demonstrated that the DNMT inhibitor 5-azacytidine can attenuate erythroid hyperplasia in the bone marrow by demethylating the VHL promoter. Azacitidine von Hippel-Lindau tumor suppressor Rattus norvegicus