Title : Amyloid β, α-synuclein and the c subunit of the ATP synthase: Can these peptides reveal an amyloidogenic pathway of the permeability transition pore?

Pub. Date : 2021 Mar 1

PMID : 33309700






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the matrix these peptides, which would fold into alpha-helical structure in native conditions, interact with cyclophilin D (CypD) and upon stimulation by elevated ROS and/or the Ca2+ spontaneously misfold into beta-sheet ion conducting pores, causing PTP opening. Reactive Oxygen Species peptidylprolyl isomerase D Homo sapiens