Title : Saturated fatty acids induce insulin resistance in podocytes through inhibition of IRS1 via activation of both IKKβ and mTORC1.

Pub. Date : 2020 Dec 10

PMID : 33303821






1 Functional Relationships(s)
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1 Our results demonstrate that saturated FFA activated the serine/threonine kinases IkappaB kinase (IKK)beta/IkappaBalpha and mTORC1/S6K1, but not protein kinase C and c-jun N-terminal kinase, in podocytes and glomeruli of db/db mice. Serine conserved helix-loop-helix ubiquitous kinase Mus musculus