Title : Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote Kras/Lkb1/Keap1 Mutant Lung Adenocarcinoma Cell Migration and Invasion.

Pub. Date : 2020

PMID : 33299528






1 Functional Relationships(s)
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1 With reduced NRF2 SUMOylation, increased ROS acted as signaling molecules to activate the JNK/c-Jun axis, which enhanced cell mobility and cell adhesion, to promote LUAD cell migration and invasion. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens