Pub. Date : 2021 Jan
PMID : 33290797
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Memantine treatment exerts an antidepressant-like effect by preventing hippocampal mitochondrial dysfunction and memory impairment via upregulation of CREB/BDNF signaling in the rat model of chronic unpredictable stress-induced depression. | Memantine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 2 | CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine. | Memantine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 3 | CUS also reduced the expression of cell survival genes, cyclic-AMP response element-binding protein (CREB), and brain-derived nerve growth factor (BDNF), which was reversed by treatment with Memantine. | Memantine | cAMP responsive element binding protein 1 | Rattus norvegicus |
| 4 | Thus, Memantine treatment exerts an antidepressant-like effect by preventing CUS induced excitotoxicity, oxidative stress, and enhancing CUS induced decrease in mitochondrial functioning and expression of cell survival genes via upregulation of stress-responsive CREB/BDNF signaling. | Memantine | cAMP responsive element binding protein 1 | Rattus norvegicus |