Title : Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils.

Pub. Date : 2020 Dec 3

PMID : 33273615






2 Functional Relationships(s)
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1 The proline-rich region of tau remains poorly defined in the context of tau amyloid structures, despite the clustering of several phosphorylation sites, which have been associated with Alzheimer"s disease. Proline microtubule associated protein tau Homo sapiens
2 In order to gain insight into the contribution of the proline-rich region P2 of tau to amyloid fibrils, we studied in vitro aggregated amyloid fibrils of tau constructs, which contain both the proline-rich region P2 and the pseudo-repeats. Proline microtubule associated protein tau Homo sapiens