Title : AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS-Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib.

Pub. Date : 2021 Feb

PMID : 33273059






1 Functional Relationships(s)
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1 Here we report the discovery and characterization of AZD0364, a novel, reversible, ATP-competitive ERK1/2 inhibitor with high potency and kinase selectivity. Adenosine Triphosphate mitogen-activated protein kinase 3 Homo sapiens