Title : Investigating the interaction between nifedipine- and ritonavir-containing antiviral regimens: A physiologically based pharmacokinetic/pharmacodynamic analysis.

Pub. Date : 2021 Jul

PMID : 33269470






4 Functional Relationships(s)
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1 Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug-drug interactions. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug-drug interactions. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 Since ritonavir is a strong inhibitor of CYP3A and nifedipine is mainly metabolized via CYP3A, the combination of ritonavir and nifedipine can potentially cause drug-drug interactions. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens
4 Model simulations showed that the inhibitory effect of ritonavir on CYP3A4 increased the Cmax of nifedipine 17.92-48.85-fold and the AUC 63.30-84.01-fold at steady state and decreased the SBP by more than 40 mmHg. Ritonavir cytochrome P450 family 3 subfamily A member 4 Homo sapiens