Title : Combinatorial Efficacy of Olaparib with Radiation and ATR Inhibitor Requires PARP1 Protein in Homologous Recombination-Proficient Pancreatic Cancer.

Pub. Date : 2021 Feb

PMID : 33268569






2 Functional Relationships(s)
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1 We tested the hypothesis that combined therapy with radiation and ATR inhibitor (AZD6738) would extend the therapeutic indication of olaparib to HR-proficient pancreatic cancers. olaparib ATR serine/threonine kinase Homo sapiens
2 DNA fiber combing revealed that high concentrations of olaparib did not stall replication forks but instead accelerated replication fork progression in association with an ATR-mediated replication stress response that was antagonized by AZD6738. olaparib ATR serine/threonine kinase Homo sapiens