Title : Cytochrome P450 expression, induction and activity in human induced pluripotent stem cell-derived intestinal organoids and comparison with primary human intestinal epithelial cells and Caco-2 cells.

Pub. Date : 2021 Mar

PMID : 33263786






1 Functional Relationships(s)
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1 Furthermore, we showed that CYP1A1 and CYP1B1 were induced by beta-naphtoflavone in all three models, whereas CYP3A4 was induced by phenobarbital and rifampicin in HIOs, in the IEC-based model (although not statistically significant), but not in Caco-2 cells. Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens