Title : DNA Double-Strand Breaks Are a Critical Regulator of Fear Memory Reconsolidation.

Pub. Date : 2020 Nov 26

PMID : 33256213






1 Functional Relationships(s)
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1 Consistent with this, in vivo siRNA-mediated knockdown of topoisomerase II beta, the enzyme responsible for DSB, prior to retrieval, reduced Npas4 promoter-specific H2A.XpS139 and H3K4me3 levels and impaired long-term memory, indicating an indispensable role of DSBs in the memory reconsolidation process. dsbs DNA topoisomerase II beta Homo sapiens