Title : Absence of Mal/TIRAP Results in Abrogated Imidazoquinolinones-Dependent Activation of IRF7 and Suppressed IFNβ and IFN-I Activated Gene Production.

Pub. Date : 2020 Nov 25

PMID : 33255528






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Activation of TLR7 by small imidazoquinoline molecules such as R848 or R837 initiates signaling cascades leading to the activation of transcription factors, such as AP-1, NF-kappaB, and interferon regulatory factors (IRFs) and afterward to the induction of cytokines and anti-viral Type I IFNs. THOS Streptonigrin FosB proto-oncogene, AP-1 transcription factor subunit Homo sapiens