Pub. Date : 2020 Dec 4
PMID : 33251049
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 2 | In this study, we report that the LINC00460-miR-149-5p/miR-150-5p-mutant p53 feedback loop is responsible for oxaliplatin resistance in CRC. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 3 | LINC00460 functions as a competing endogenous RNA (ceRNA) to promote oxaliplatin resistance through sequestering miR-149-5p/miR-150-5p and upregulating the expression of the microRNA (miRNA) target p53. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 4 | Knockdown of LINC00460 sensitized SW480/OxR cells to oxaliplatin by modulating p53 in vitro and in vivo. | Oxaliplatin | tumor protein p53 | Homo sapiens |
| 5 | Our findings uncover a mechanism for the LINC00460-miR-149-5p/miR-150-5p-mutant p53 feedback loop in oxaliplatin resistance of CRC, and they provide potential therapeutic targets for tumor chemoresistance. | Oxaliplatin | tumor protein p53 | Homo sapiens |