Title : Design, synthesis, biological evaluation, and docking studies of some novel chalcones as selective COX-2 inhibitors.

Pub. Date : 2021 Mar

PMID : 33244799






1 Functional Relationships(s)
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1 Enzyme inhibition studies revealed that most of the compounds showed a moderate-to-strong inhibitory activity (IC50 = 0.18-0.34 muM) against the COX-2 enzyme as compared with celecoxib (IC50 = 0.12 muM), ibuprofen (IC50 = 5.33 muM), and nimesulide (IC50 = 1.68 muM). nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens