Title : The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state.

Pub. Date : 2021 Feb

PMID : 33230593






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1 Mechanistically, a high extracellular lactate-to-pyruvate ratio decreases the activation of JNK and Bax under oxidative stress, thereby inhibiting the intrinsic apoptotic pathway. Pyruvic Acid BCL2 associated X, apoptosis regulator Homo sapiens