Title : The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling.

Pub. Date : 2020 Nov 23

PMID : 33228717






7 Functional Relationships(s)
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1 The COX-2-derived PGE2 autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
2 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
3 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
4 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
5 The raised BK may be detrimental effects on the CNS that may aggravate brain inflammation through MMP-9 up-regulation or cyclooxygenase-2 (COX-2)-derived prostaglandin E2 (PGE2) production in brain astrocytes. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
6 However, the relationship between BK-induced MMP-9 expression and COX-2-derived PGE2 release in brain astrocytes remains unclear. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus
7 RESULTS: Our results show activation of native COX-2 by BK led to PGE2 production and release. Dinoprostone prostaglandin-endoperoxide synthase 2 Rattus norvegicus