Title : OSI-027 Alleviates Oxaliplatin Chemoresistance in Gastric Cancer Cells by Suppressing P-gp Induction.

Pub. Date : 2021

PMID : 33222668






1 Functional Relationships(s)
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1 At the molecular level, OSI-027 simultaneously blocked mTORC1 and mTORC2 activation, and resulted in the downregulation of phosphor-Akt, phpspho-p70S6k, phosphor-4EBP1, cyclin D1, and cyclin-dependent kinase4 (CDK4). OSI 027 AKT serine/threonine kinase 1 Homo sapiens