Title : Esculetin protects human corneal epithelial cells from oxidative stress through Nrf-2 signaling pathway.

Pub. Date : 2021 Jan

PMID : 33220236






1 Functional Relationships(s)
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1 Our data revealed that esculetin played an antioxidant role not only through its antioxidant activity, but also by highly inducing Nrf-2 translocation to the nucleus, which in turn, enhanced Nrf2 signaling regulated antioxidant genes (HO-1, NQO1, GCLM, SOD1 and SOD2) mRNA expression levels in H2O2-treated HCE cells. esculetin heme oxygenase 1 Homo sapiens