Pub. Date : 2020 Nov 17
PMID : 33212830
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The calculated binding free energies of the O-methylated flavonoids (1 and 4-6) and chalcones (2 and 3) to MAO-A matched closely with the trend in the experimental IC50"s. | Flavonoids | monoamine oxidase A | Homo sapiens |
| 2 | The natural O-methylated flavonoid (1) with highly potent inhibition (IC50 33 nM; Ki 37.9 nM) and >292 fold selectivity against human MAO-A (vs. MAO-B) provides a new drug lead for the treatment of neurological disorders. | Flavonoids | monoamine oxidase A | Homo sapiens |