Title : Design and synthesis of novel isatin-based derivatives targeting cell cycle checkpoint pathways as potential anticancer agents.

Pub. Date : 2020 Dec

PMID : 33212312






1 Functional Relationships(s)
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1 Docking studies on CDK1 revealed that the active molecules bind to the tested enzyme by the same manner of the co-crystallized ligands and the isatin-thiazoldinone/ene scaffold is essential for binding of these molecules. isatin-thiazoldinone cyclin dependent kinase 1 Homo sapiens