Title : Synergistic targeting of CHK1 and mTOR in MYC-driven tumors.

Pub. Date : 2021 Apr 17

PMID : 33206174






1 Functional Relationships(s)
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1 Mechanistically, rapamycin inactivates carbamoyl-phosphate synthetase 2, aspartate transcarbamoylase, and dihydroorotase (CAD), the essential enzyme for the first three steps of de novo pyrimidine synthesis, and deteriorates CHIR-124-induced replicative stress. Sirolimus aconitate decarboxylase 1 Homo sapiens