Title : The effect of emodin on melanogenesis through the modulation of ERK and MITF signaling pathway.

Pub. Date : 2022 Feb

PMID : 33205668






4 Functional Relationships(s)
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1 Emodin increased not only tyrosinase activity but also melanin synthesis in vitro. Emodin tyrosinase Mus musculus
2 Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence. Emodin tyrosinase Mus musculus
3 Moreover, emodin enhanced melanin synthesis by increasing the expression level of tyrosinase (TYR), tyrosine related protein (TRP)-1, TRP-2, MITF and SIRT1 proteins in live cells treated with H2O2 compared with H2O2 treatment group in the analyses of western blot and immunofluorescence. Emodin tyrosinase Mus musculus
4 Thus, emodin promoted melanin synthesis by increasing the expression of TRP-1, TRP-2, tyrosinase through the activation of MITF transcription factor. Emodin tyrosinase Mus musculus