Title : AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.

Pub. Date : 2021 Jan

PMID : 33203990






2 Functional Relationships(s)
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1 Mechanistically, AMD1 depletion induced loss of mitochondrial membrane potential and accumulation of reactive oxygen species (ROS), resulting in the differentiation of LSCs via oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was partially rescued by the addition of polyamine. Reactive Oxygen Species adenosylmethionine decarboxylase 1 Homo sapiens
2 Mechanistically, AMD1 depletion induced loss of mitochondrial membrane potential and accumulation of reactive oxygen species (ROS), resulting in the differentiation of LSCs via oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was partially rescued by the addition of polyamine. Reactive Oxygen Species adenosylmethionine decarboxylase 1 Homo sapiens