Pub. Date : 2021 Feb
PMID : 33201408
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexamethasone upregulates mitochondrial Tom20, Tom70, and MnSOD through SGK1 in the kidney cells. | Dexamethasone | superoxide dismutase 2 | Homo sapiens |
| 2 | Similarly, dexamethasone significantly increased MnSOD transcripts by 67 +- 15% and protein level only in the mitochondria dose-dependently. | Dexamethasone | superoxide dismutase 2 | Homo sapiens |
| 3 | Finally, knock-down of Tom20 and Tom70 by their siRNAs reduced dexamethasone-induced increases in the mitochondrial localization of SGK1 and MnSOD proteins. | Dexamethasone | superoxide dismutase 2 | Homo sapiens |
| 4 | In conclusion, dexamethasone upregulates Tom20, Tom70, and MnSOD, and these effects are dependent on reactive oxygen species and SGK1. | Dexamethasone | superoxide dismutase 2 | Homo sapiens |
| 5 | Dexamethasone-induced increases of SGK1 and MnSOD mitochondrial localization requires Tom20 and Tom70. | Dexamethasone | superoxide dismutase 2 | Homo sapiens |