Title : Serum 4β-hydroxycholesterol increases during fluconazole treatment.

Pub. Date : 2021 May

PMID : 33201347






1 Functional Relationships(s)
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1 PURPOSE: The antifungal drugs ketoconazole and itraconazole reduce serum concentrations of 4beta-hydroxycholesterol, which is a validated marker for hepatic cytochrome P450 (CYP) 3A4 activity. cholest-5-ene-3,4-diol cytochrome P450 family 3 subfamily A member 4 Homo sapiens