Title : Dimethyl fumarate protects nucleus pulposus cells from inflammation and oxidative stress and delays the intervertebral disc degeneration.

Pub. Date : 2020 Dec

PMID : 33199994






2 Functional Relationships(s)
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1 DMF also increased the activity of the nuclear factor erythroid 2-related factor (Nrf) 2/heme oxygenase (HO)-1 signaling pathway in NP cells and increased the phosphorylation of Akt. Dimethyl Fumarate AKT serine/threonine kinase 1 Homo sapiens
2 DMF also increased the anti-inflammatory and antioxidative ability of NP cells by promoting the activity of the Nrf2/HO-1 and PI3K/Akt signaling pathways, thus delaying IVDD. Dimethyl Fumarate AKT serine/threonine kinase 1 Homo sapiens