Title : Metabolic interaction between amino acid deprivation and cisplatin synergistically reduces phosphoribosyl-pyrophosphate and augments cisplatin cytotoxicity.

Pub. Date : 2020 Nov 16

PMID : 33199755






1 Functional Relationships(s)
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1 The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced intracellular PRPP availability. NAD poly (ADP-ribose) polymerase family, member 1 Mus musculus