Title : Pathomechanism characterization and potential therapeutics identification for SCA3 targeting neuroinflammation.

Pub. Date : 2020 Nov 10

PMID : 33196459






1 Functional Relationships(s)
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1 In retinoic acid-differentiated ATXN3/Q75-GFP SH-SY5Y cells inflamed with IFN-gamma-primed HMC3 conditioned medium, treatment with the tested compounds mitigated the increased caspase 1 activity and lactate dehydrogenase release, reduced polyQ aggregation and ROS and/or promoted neurite outgrowth. Reactive Oxygen Species interferon gamma Homo sapiens